Assistant Research (Pej-2024-Ai/Sal-Gl-32563) (Am)

Translational Research in Childhood Cancer, Haematopoietic Transplantation and Cell Therapy GroupOrganisation/Company: IdiPAZDepartment: Translational Research in Childhood Cancer, Haematopoietic Transplantation and Cell Therapy GroupResearch Field: Biological sciences » BiologyCountry: SpainApplication Deadline: 25 Jan 2025 – 23:00 (Europe/Brussels)Type of Contract: PermanentJob Status: Full-timeHours Per Week: 37.50Offer Starting Date: 1 Feb 2025Offer DescriptionIdiPAZ is looking for a research assistant in a research project co-financed by the Community of Madrid and the European Social Fund Plus (ESF+), 2021-2027, for the Pediatric Extracranial Solid Tumors group, led by Dr. Adriana Mañas, and part of the Translational Research in Childhood Cancer, Hematopoietic Transplantation, and Cell Therapy (GICITT) group, led by Dr. Pérez-Martínez, within the Biomedical Research Foundation of La Paz University Hospital (IdiPAZ).The candidate will participate directly in the projects led by Dr. Mañas, especially in the paediatric avatars project, focused on the creation and characterisation of patient-derived models (in vivo and in vitro) and their use as avatars to develop new personalised treatments for paediatric solid tumours (neuroblastoma, hepatoblastoma, nephroblastoma and sarcoma).Objectives of the main project:Implantation of patient tumour samples in immunosuppressed mice (PDX models).Treatment of PDX models with chemotherapy and characterisation of tumour response by RNA analysis and histological techniques.Establishment of in vitro organoid models from PDX models and characterisation of the response to chemotherapy in vitro.Use in vitro (organoid) and in vivo (PDX) models to test and validate new therapies in comparison with standard chemotherapy.Activities and functions:Processing of patient tumour samples, both to preserve viability and for implantation in animals.Collaboration in the process of PDX implantation, monitoring and treatment of mice, and collection and processing of tumours for different analyses.Establishment of in vitro PDX-derived tumour organoid cultures.Extraction and basic bioinformatics analysis of RNA from tumours and organoids.Processing of tumours and organoids for histological analysis.Treatment of tumour organoids with different therapies and analysis of viability and cytotoxicity.Where to applyE-mail: ****** Level: Master Degree or equivalentSkills/Qualifications:BiologyMaster’s Degree in Molecular Biology/Biomedicine/Translational Medicine or similarHighly motivated professionalAnalytical and organisational skillsTeamworkSpecific Requirements:Master’s degree in Molecular Biology/Biomedicine/Translational Medicine or similar.Previous experience in cell culture.Basic experience in biomolecular analysis techniques such as Western Blot, DNA/RNA extraction, PCR, etc.High level (C1) of spoken and written English.Advanced knowledge of Microsoft Office (Word, Excel, Powerpoint).A positive assessment would be an asset:Previous experience in tumour organoid culture.Experience with paediatric cancer models.Possession of a certificate for working with animals (Functions A, B and C).Knowledge of specific software such as GraphPad, FlowJo or ImageJ.Excluding requirements for access to the process in accordance with the public call of the Community of Madrid:Be under 30 years of age on the date of contracting with the beneficiary entity.Be unemployed until the day before the date of contracting with the beneficiary entity.Incompatibility to have any other employment contract from the date of contracting.Languages:ENGLISH: ExcellentSPANISH: ExcellentYears of Research Experience: 1 – 4Additional InformationWorking conditions:Contract for scientific and technical activities.Professional category of Higher Graduate or Graduate, Group II, Area 2, according to the collective bargaining agreement.Full time of 37.5 hours per week.Gross annual salary: €17.400Private matters: 6 working days per year.Vacation: 22 working days per year.December 24 and 31 are non-business days.Eligibility criteria:The selection process will consist of two phases and the following scale will be applied, out of a maximum of 10 points:Training and curricular merits: 6 points.Personal interview: 4 points.In the event that two or more candidates match the values and needs of the institution and meet the conditions required for the post, and where there is a tie, the candidate with a certificate attesting to a minimum degree of disability equal to or greater than 33 per cent shall prevail.Selection process:Once candidates send their application to the IdiPAZ email address, their applications are stored until the deadline for receipt of applications for the offer is up.

The HR department of IdiPAZ will make a first selection of applications selecting those who meet the criteria required in the offer.

The selected applications are then evaluated by the selection committee, composed of the head of human resources at IdiPAZ, the President of the IdiPAZ Internal Scientific Committee and the Project Manager which will apply the scales described in each call for applications.

Once the candidate is selected, he/she will be contacted by the HR department of IdiPAZ to provide the required documentation.Additional comments:Contract co-financed by the Community of Madrid and the European Social Fund Plus (ESF+), 2021-2027, with reference PEJ-2024-AI/SAL-GL-32563.Applications shall be submitted in the following manner:- Send CV to: ******.

In the subject of the e-mail, please indicate the reference “Assistant Research (PEJ-2024-AI/SAL-GL-32563) (MG)”.Work Location(s)Number of offers available: 1Company/Institute: Fundación para la Investigación Biomédica del Hospital Universitario La PazCountry: SpainState/Province: MadridCity: MadridPostal Code: 28046Street: Paseo Castellana 261

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