Research Fellow (Cancer Science Institute)

Job Description

The ADJ Laboratory at Cancer Science Institute, focuses on understanding the immune system’s recognition of cancer cells after DNA-damaging chemotherapy. The lab’s goal is to guide the rational design of immunotherapy-chemotherapy combinations for cancer treatment, with a particular emphasis on lymphomas and collaborations with the NUH Lymphoma team. The Research Fellow will play a pivotal role in advancing these efforts by conducting cutting-edge research at the intersection of molecular and cellular biology, immunology, and translational cancer therapy.

• Conduct Research:
• Investigate intracellular mechanisms in cancer cells influencing immune activation after DNA damage.
• Develop and evaluate combination strategies to enhance the efficacy of genotoxic chemotherapy using cell-intrinsic and cell-extrinsic approaches.
• Experimental Design and Execution:
• Utilize cell line models for epithelial and lymphoid cancers to study DNA repair and immune activation mechanisms.
• Design and perform in-vitro assays and systems to analyze immunogenic responses to chemotherapy.
• Perform quantitative microscopy on histological material to explore immune modulation pathways.
• Data Analysis and Dissemination:
• Analyze experimental results, interpret findings, and prepare research publications in high-impact journals.
• Present research outcomes at local and international conferences.
• Collaborations:
• Work closely with local and international collaborators for clinical sample acquisition and analysis.
• Partner with pharmaceutical and medical technology companies to facilitate clinical translation and biomarker development.
• Mentorship and Supervision:
• Provide guidance and mentorship to graduate students, post-doctoral researchers, elective students, and medical trainees involved in the lab’s projects.
• Research Development:
• Contribute to securing research funding through grant proposals and fostering academic-industry collaborations.

Qualifications

• Education and Experience:
• Ph.D. in Molecular Biology, Immunology, Cancer Biology, or a related field.
• Experience in translational cancer research and familiarity with immune-oncology.
• Technical Skills:
• Proficiency in cell culture, molecular biology, and immunological assays.
• Experience with DNA repair assays, flow cytometry, and quantitative microscopy.
• Competence in bioinformatics and data analysis tools will be advantageous.
• Soft Skills:
• Strong analytical and problem-solving abilities.
• Excellent communication skills and the ability to work collaboratively in a diverse team.
• Commitment to promoting diversity and mutual respect in science.
• Additional Attributes:
• Proven track record of scientific publications and presentations.
• Ability to manage multiple projects and meet deadlines.
• Familiarity with clinical sample handling and translational research methodologies.